About Us General Research Landscape Research Cases Research Funding Schemes Common Tips for Application Career Development
About Us General Research Landscape Research Cases Research Funding Schemes Common Tips for Application Career Development
EN

Can wearing masks control the spread of influenza or even COVID-19?

Can wearing masks control the spread of influenza or even COVID-19?
Indeed, it was a significant discovery by a research team in Hong Kong!

When reports emerged of COVID-19 at the end of 2019, people realised the outbreak should not be taken lightly and voluntarily wore masks to prevent its spread. For years, people have worn masks to prevent the spread of influenza and other respiratory diseases. But there was little evidence of the impact of wearing masks on reducing the spread of infectious airborne droplets.

In 2015, Professor Malik Peiris from The University of Hong Kong started a research regarding influenza virus transmission. When the COVID-19 pandemic began in 2020, the only measures available for containment were non-pharmaceutical interventions in nature i.e. measures that interrupt transmission. Although the primary focus of the research project was to understand the transmission of influenza, data was also gathered on other seasonal coronaviruses that cause respiratory disease. One of these studies showed that the use of surgical masks reduced the spread of airborne particles from coronavirus infected patients, information was also relevant to SARS-CoV-2. Thus, the research program not only provided new findings of importance for the control of influenza but also provided key knowledge early on to help control the spread of SARS-CoV-2.

Continue

In 2015, Malik Peiris, Professor and Chair in Virology at the School of Public Health, The University of Hong Kong, and his team of scientists, ranging from virologists, epidemiologists, clinicians, pathologists, and engineers, rolled up their sleeves in the lab and started working on a project that was of vital importance to humans– “Viral, Host and Environmental Determinants of Influenza Virus Transmission and Pathogenesis”.

Influenza is a major threat to global public health. Hong Kong is situated at an epicentre of pandemic emergence. Pandemic influenza arises from animals at unpredictable intervals and can spread worldwide within weeks. Seasonal influenza is a predictable yearly occurrence that is associated with significant morbidity and mortality.

The team realised that understanding the transmission of respiratory viruses was of foremost importance for the protection of public health. They hoped to understand its scientific basis and identifying options for influenza control and aimed to learn more about animals-to-humans and humans-to-humans influenza transmission as well as providing insights on novel treatment options such as new-generation influence vaccines.

Professor and Chair in Virology at the School of Public Health, The University of Hong Kong Malik Peiris

Continue

The research team established a multi-disciplinary influenza research program which has contributed to public health responses locally and globally. They have investigated the viral, host and environmental factors that allow animal viruses to adapt to humans and also helped improve risk-assessment of animal viruses for pandemic or zoonotic threat contributing and enhancing global pandemic preparedness and providing evidence-based interventions to contain emerging threats. The team has worked with local governmental departments to reduce the threat of avian influenza outbreaks in Hong Kong. They have also investigated the factors that pre-dispose to the transmission of seasonal influenza viruses in humans by studying influenza transmission within families and hospital settings. These studies helped provide an understanding of the mechanisms of influenza transmission and allowed evidence-based interventions that can reduce influenza virus transmission within the community and hospitals.

Research is never easy. Thanks to the team’s hard work, the public has been provided with a considerable amount of important information and new insights regarding influenza transmission.

Continue
Contribution to influenza and COVID-19 control

As mentioned earlier, the efforts of Professor Peiris and his team have led to a lot of knowledge about the transmission of influenza viruses. When COVID-19 spread around the world, this knowledge was shared to assist early outbreak control providing vital support to the medical community.

• The team demonstrated the release of airborne particles carrying the virus from patients infected with influenza and other seasonal coronaviruses and showed that the release of infectious coronaviruses was markedly reduced by wearing a surgical mask. The research paper published in early 2020 was one of the most downloaded papers (2 million downloads) in the first weeks after publication and provided one of the scientific basis for recommending the strategy of “universal masking” for the containment of COVID-19.

• For the first time, the team developed methods to quantitate the size of infectious airborne droplets that can transmit influenza in an experimental animal model, the ferret. This strategy has now been applied to humans and also to deal with the airborne transmission of COVID-19. The team developed an experimental hamster animal model to investigate the transmission of SARS-CoV-2. These experiments also demonstrated the duration of transmissibility of both influenza and COVID-19.

• They carried out studies of influenza virus transmission within families in the community. The team showed that clinical illness profiles serve as a correlate for clinical infectiousness in influenza A virus infections but patients with influenza B may potentially be infectious even before onset of symptoms or after clinical improvement. They found that the presence of respiratory symptoms in a patient does not influence transmission probabilities with the exception of children and showed that antiviral (oseltamivir) treatment of index patients did not appear to reduce household transmission.

• Severe respiratory viruses such as avian influenza, SARS and COVID-19 lead to severe disease and death by leading to acute lung injury and respiratory failure. The team found targeted ways to improve survival through intervening the mechanisms of acute lung injury by avian influenza H5N1. This may be useful for the treatment of severe respiratory disease induced by viruses such as avian flu, SARS and COVID-19.

Continue
Key Contributions & Significance

The findings of the research have made a significant impact on the control of COVID-19 and public health. Let’s take a look at the key contributions below!

Led WHO’s early guidance on non-pharmaceutical COVID-19 interventions

Professor Ben Cowling, who was on the research team, led and prepared a
document titled “Non-pharmaceutical Public Health Measures for Mitigating the Risk and Impact of Epidemic and Pandemic Influenza”, which also served as an early guide to preventing COVID-19 transmission in non-pharmaceutical ways.

Moreover, the team participated in numerous of local and international policymaking events for the containment of COVID-19 and influenza.

Developed diagnostic methods for SARS-CoV-2

The team developed and shared the diagnostic methods for SARS-CoV-2. The team shared the reagents with more than 140 laboratories benefitting people from over 70 countries. Before commercial testing kits were made available to the public, these diagnostic methods were shared immediately via WHO’s website and some countries used their reagents to detect the first cases of SARS-CoV-2.

Published over 150 research papers in international journals

So far, the team has published more than 150 peer-reviewed international papers in publications such as Nature, Science, The Lancet Infectious Disease and The Lancet Respiratory Medicine, which have been cited more than 4,800 times in total.

Provided the scientific evidence supporting “universal masking”

The research provided the public with scientific evidence which supported the principle of “universal masking” in the face of respiratory virus pandemic. This strategy has played an important role in the containment of COVID-19.

Provided real-time data to WHO and FAO and participated in WHO Influenza vaccine strain selection meetings

The team provided real-time data on newly emerged virus pathogens, such as H7N9 and H5N6, to WHO, FAO, and other international agencies, which helped assess the risks of COVID-19 and prepared the use of vaccines. They also participated in biannual meetings of influenza vaccine strain selection by WHO and contributed to the development and evaluation of the organisation’s “Tool for Influenza Pandemic Risk Assessment”.

Advised Hong Kong Food and Environmental Hygiene Department on modifications implemented in Hong Kong’s live poultry markets

The team found out that the defeathering machines used in live poultry markets generated infectious airborne particles and advised the department on modifications implemented in the city’s live poultry markets so that zoonotic risk from avian influenza can be further reduced. They also sent in submissions to the Legislative Council of Hong Kong regarding the “Study of the Way Forward for the live poultry trade in Hong Kong”.

Nurtured the next generation

Professor Peiris and his team are also committed to nurturing and training the next generation of researchers. “Little Dr Flu”, an outreach program for primary schools, teaches students about influenza and respiratory infections. In addition, a total of 53 postgraduate research students were trained and postdoctoral fellows and research assistant professors are promoted to tenure-track academics in Hong Kong and overseas.